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      Pharmaceutical intermediates

      Anti-tumor drugs

      Name

      Key intermediate

      CAS NO
      Axitinib

      3,6-diiodo(1H)indazole

      Methyl 2-mercaptobenzoate

      319472-78-1

      4892-02-8

      Crizotinib

      4-Iodo-1H-pyrazole

      (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

      4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

      (R)-5-bromo-3-(1-

      3469-69-0

      877397-70-1

      877399-50-3

      877399-00-3

      Lapatinib

      2-(Methylsulfonyl)-ethanamine hydrochloride

      N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

      3-Chloro-4-(3-fluorobenzyloxy)aniline

      104458-24-4

      231278-20-9

      202197-26-0

      Pazopanib

      3-Methyl-6-nitro-1H-Indazole

      2,3-dimethyl-6-nitro-2H-indazole

      2,3-dimethyl-2H-indazol-6-amine

      2,4-Dichloropyrimidine

      3-Amino-6-methylbenzenesulfonam

      6494-19-5

      444731-73-1

      444731-72-0

      3934-20-1

      6973-09-7

      Regorafenib

      3-Fluoro-4-Nitrophenol

      3-Fluoro-4-aminophenol

      394-41-2

      399-95-1

      Afatinib

      trans 4-Dimethylaminocrotonic acid hydrochloride

      848133-35-7

      Gefitinib

      4-(3-chloropropyl)-morpholin

      7357-67-7

      Anti-inflammatory drugs

      Name

      Key intermediate

      CAS NO
      Tofacitinib

      1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate

      (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride

      2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine

      3-bis(4-

      493040-20-3

      477600-70-7

      90213-66-4

      477600-71-8

      Formoterol

      2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

      (1R,2S)-1-Amino-2-indanol

      43229-01-2

      136030-00-7

      Umeclidiniu

      Phenyl(piperidin-4-yl)methanone

      37586-22-4

      Hypoglycemic agents

      Name

      Key intermediate

      CAS NO
      Alogliptin

      (R)-3-Boc-aminopiperidine

      309956-78-3

      Anagliptin

      2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid

      2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

      1,2-Diamino-2-methylpropane

      739364-95-5

      338953-49-4

      811-93-8

      Dapagliflozin

      5-Bromo-2-chloro-4’-ethoxydiphenylmethane

      4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene

      (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

      461432-23-5

      1103738-29-9

      461432-22-4

      Vildagliptin

      3-Amino-1-adamantanol

      (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

      L-Prolinamide

      702-82-9

      207557-35-5

      7531-52-4

      Canagliflozin

      2-(4-fluorophenyl)thiophene

      (5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanone

      2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene

      (5-bromo-2-methylph

      58861-48-6

      1071929-08-2

      898566-17-1

      1132832-75-7

      1030825-20-7

      Anticoagulants drugs

      Name

      Key intermediate

      CAS NO
      Dabigatran

      N-(4-Cyanophenyl)glycine

      4-(Methylamino)-3-nitrobenzoic Acid

      3-(Pyridin-2-ylamino)propanoate

      Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta-alaninate

      42288-26-6

      41263-74-5

      103041-38-9

      212322-56-0

      Ticagrelor

      4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine

      (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine

      (1R,2R)-2-(3,4-difluorophenyl) cyclopropanamine(S)-(carboxylato(phenyl) methyl)h

      145783-14-8

      220352-38-5

      376608-71-8

      Antiepileptics drugs

      Name

      Key intermediate

      CAS NO
      Retigabine (ezogabine)

      2-Amino-5-[(4-fluorobenzyl)amino]-1-nitrobenzene

      4-(4-Fluorobenzylamino)-1,2-phenylenediamine

      150812-21-8

      491871-67-1

      Anti-HIV drugs

      Name

      Key intermediate

      CAS NO
      Abacavir

      (2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

      (1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-Cyclopentene-1- methano

      171887-03-9

      136522-33-3

      Etravirine

      (4-Cyanophenyl)guanidine

      4-Aminobenzonitrile

      5637-42-3

      873-74-5

      Ritonavir

      154212-59-6

      154212-61-0

      144164-11-4

      154212-59-6

      154212-61-0

      144164-11-4

      Atazanavir

      4-(2-Pyridinyl)- benzaldehyde

      N-(Methoxycarbonyl)-L-tert-leucine

      Tert-Butyl[(1S)-1-(2R)-Oxiranyl-2-Phenylethyl]carbamate

      2-[[4-(2-Pyridinyl)phenyl]methylene]- hydrazin

      127406-56-8

      162537-11-3

      98760-08-8

      198904-84-6

      198904-86-8

      Aliskiren

      5-Bromo 2-methoxy phenol

      37942-01-1

      Antihypertensives drugs

      Name

      Key intermediate

      CAS NO
      Aliskiren

      5-Bromo 2-methoxy phenol

      37942-01-1

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